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Stadler, M., Dagne, E., & Anke, H. (1994). Nematicidal activities of two phytoalexins from taverniera abyssinica. Planta Medica, 60(6), 550–552. 
Resource type: Journal Article
DOI: 10.1055/s-2006-959569
ID no. (ISBN etc.): 0032-0943
BibTeX citation key: Stadler1994
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Categories: General
Keywords: 4-hydroxymedicarpin, antimicrobial activity, cytotoxic activity, leguminosae, medicarpin, nematicidal activity, Taverniera abyssinica
Creators: Anke, Dagne, Stadler
Collection: Planta Medica
Attachments   URLs   http://www.thieme- ... 1055/s-2006-959569
The traditional analgesic and antipyretic Ethiopian drug 'Dingetegna' is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, 'Dingetegna' extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxymedicarpin were isolated as nematicidal constituents from the extracts. In a microwell plate assay for nematicidal activity, both compounds exhibited an LD50 of 25 $μ$g/ml towards C. elegans. Beside these nematicidal effects, weak cytotoxic and antimicrobial activities were observed. In addition, both compounds inhibited oxygen consumption of axenically grown C. elegans, L 1210 cells, and filamentous fungi. Respiration in sensitive bacteria was not affected. In L 1210 cells, the incorporation of precursors into macromolecules was affected in the presence of glucose, indicating that inhibition of respiration is not the only target site of the compounds.