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Stadler, M., Dagne, E., & Anke, H. (1994). Nematicidal activities of two phytoalexins from taverniera abyssinica. Planta Medica, 60(6), 550–552. |
| Resource type: Journal Article DOI: 10.1055/s-2006-959569 ID no. (ISBN etc.): 0032-0943 BibTeX citation key: Stadler1994 View all bibliographic details  |
Categories: General Keywords: 4-hydroxymedicarpin, antimicrobial activity, cytotoxic activity, leguminosae, medicarpin, nematicidal activity, Taverniera abyssinica Creators: Anke, Dagne, Stadler Collection: Planta Medica |
| Attachments | URLs http://www.thieme- ... 1055/s-2006-959569 |
| Abstract |
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The traditional analgesic and antipyretic Ethiopian drug 'Dingetegna' is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, 'Dingetegna' extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxymedicarpin were isolated as nematicidal constituents from the extracts. In a microwell plate assay for nematicidal activity, both compounds exhibited an LD50 of 25 $μ$g/ml towards C. elegans. Beside these nematicidal effects, weak cytotoxic and antimicrobial activities were observed. In addition, both compounds inhibited oxygen consumption of axenically grown C. elegans, L 1210 cells, and filamentous fungi. Respiration in sensitive bacteria was not affected. In L 1210 cells, the incorporation of precursors into macromolecules was affected in the presence of glucose, indicating that inhibition of respiration is not the only target site of the compounds.
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