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Tchoumbougnang, F., Zollo, P. H. A., Dagne, E., & Mekonnen, Y. (2005). In vivo antimalarial activity of essential oils from cymbopogon citratus and ocimum gratissimum on mice infected with plasmodium berghei. Planta Medica, 71(1), 20–23. 
Resource type: Journal Article
DOI: 10.1055/s-2005-837745
ID no. (ISBN etc.): 320943
BibTeX citation key: Tchoumbougnang2005
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Categories: General
Keywords: $β$-phellandrene, Antimalarial activity, Cymbopogon citratus, Essential oils, Geranial, Gramineae, Lamiaceae, Malaria, Ocimum gratissimum, Parasitaemia, Plasmodium berghei
Creators: Dagne, Mekonnen, Tchoumbougnang, Zollo
Collection: Planta Medica
Attachments   URLs   http://www.thieme- ... 1055/s-2005-837745
The essential oils obtained by hydrodistillation from fresh leaves of Cymbopogon citratus and Ocimum gratissimum growing in Cameroon were analyzed by GC and GC/MS. The main constituents of the oil of Ocimum gratissimum were $γ$-terpinene (21.9%), $β$-phellandrene (21.1%), limonene (11.4%) and thymol (11.2%), while the oil of Cymbopogon citratus contained geranial (32.8%), neral (29.0%), myrcene (16.2%) and $β$-pinene (10.5%). The effects of these oils on the growth of Plasmodium berghei were investigated. Both oils showed significant antimalarial activities in the four-day suppressive in vivo test in mice. At concentrations of 200, 300 and 500 mg/kg of mouse per day, the essential oil of C. citratus produced the highest activity with the respective percentages of suppression of parasitaemia: 62.1%, 81.7% and 86.6%. The corresponding values for the oil of O. gratissimum at the same concentrations were 55.0%, 75.2% and 77.8%, respectively. Chloroquine (10 mg/kg of mouse, positive control) had a suppressive activity of 100%.