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Dikasso, D., Makonnen, E., Debella, A., Abebe, D., Urga, K., & Makonnen, W., et al. (2006). Anti-malarial activity of withania somnifera l. dunal extracts in mice. Ethiopian Medical Journal, 44(3), 279–285. 
Resource type: Journal Article
ID no. (ISBN etc.): 141755
BibTeX citation key: Dikasso2006
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Categories: General
Keywords: abstracts, bioinformatics, biological patents, biomedical journals, biomedical research, citation networks, citation search, clinical guidelines, Europe PMC, Europe PubMed Central, full text, journal articles, life sciences, literature search, open access, ORCIDs, research articles, REST APIs, text mining
Creators: Abebe, Debella, Dikasso, Guta, Kassa, Makonnen, Makonnen, Melaku, Urga
Collection: Ethiopian Medical Journal
Attachments   URLs   https://europepmc. ... ticle/med/17447395
Objective: This study aims at investigating the in vivo antiplasmodial activity of a traditionally used medicinal plant, Withania somnifera, L. Dunal, (Solanaceae). Methods: Rodent malaria parasite, Plasmodiiim berghei, 0.2 ml of 1×107 parasites, was inoculated into Swiss albino mice intraperitoneally. Extracts were administered by intra gastric tube daily for four days starting from the day of parasite inoculation. Negative controls received the same amount of solvent used to suspend the extracts and the positive-controls were given chloroquine by the same route. Parasite suppressive effect and effects on body weight, packed cell volume (PCV) and body temperature were determined. Results: Parasitemia percent inhibition of W. somnifera roots and root barks were 50.43% and 29.13% respectively, with 600 mg/kg dose. Inhibition was statistically significant at all dose levels, compared to the negative controls (p<0.05), and maximum inhibition was seen at 600 mg/kg. Conclusion: Extracts of the leaves and root barks of W. somnifera showed parasite suppressive effect and a protective effect on PCV drop (at higher doses), both in dose-related fashions. However, the effects on body weight and body temperature falls are inconclusive.