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Wube, A. A., Bucar, F., Gibbons, S., & Asres, K. (2005). Sesquiterpenes from warburgia ugandensis and their antimycobacterial activity. Phytochemistry, 66(19), 2309–2315. |
| Resource type: Journal Article DOI: 10.1016/j.phytochem.2005.07.018 ID no. (ISBN etc.): 319422 BibTeX citation key: Wube2005a View all bibliographic details  |
Categories: General Keywords: 11-olide, 12-dial, 12-olide, 4(13), 6$α$, 7- coloratadien-11, 7-Coloratadien-12, 7$β$-Hydroxy-4(13), 8-coloratadien-11, 9$α$-Dihydroxy-4(13), Antimycobacterial activity, Canellaceae, Coloratane sesquiterpenes, Drimane sesquiterpenes, Warburgia ugandensis Creators: Asres, Bucar, Gibbons, Wube Collection: Phytochemistry |
| Abstract |
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The dichloromethane extract of the stem bark of Warburgia ugandensis afforded three new coloratane sesquiterpenes, namely: 6$α$,9$α$- dihydroxy-4(13),7-coloratadien-11,12-dial (1), 4(13),7-coloratadien-12,11-olide (2), and 7$β$-hydroxy-4(13),8-coloratadien-11,12-olide (3), together with nine known sesquiterpenes, i.e., cinnamolide-3$β$-acetate (4), muzigadial (5), muzigadiolide (6), 11$α$-hydroxymuzigadiolide (7), cinnamolide (8), 7$α$-hydroxy-8-drimen-11,12-olide (9), ugandensolide (10), mukaadial (11), ugandensidial (12), and linoleic acid (13). Their structures were assigned on the basis of 1D and 2D-NMR spectroscopic and GC-MS analysis. The compounds were examined for their antimycobacterial activity against Mycobacterium aurum, M. fortuitum, M. phlei and M. smegmatis; and the active constituents showed MIC values ranged from 4 to128 $μ$g/ml compared to the antibiotic drugs ethambutol (MIC ranged from 0.5 to 8 $μ$g/ml) and isoniazid (MIC ranged from 1 to 4 $μ$g/ml). ©2005 Elsevier Ltd. All rights reserved.
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